With continuous efforts in researching, in 2018, TTU’s School of Medicine has achieved admirable results with 14 topics and research projects in the field of cardiovascular. TTU medical students partially contributed to the results of those studies as co-authors, making abstract reports at international conferences and their reports were published in the Journal of the American College of Cardiology (JACC). At JACC annual meeting, Prof. Thach Nguyen was interviewed on TCTMD TV channel for his research, on Cavitation theory that induces cholesterol in coronary arteries.
These research projects are all clinical, innovatory and essential to the field of cardiology. These projects are helping to find a cause or to figure out new ways of improving coronary risk interventions. Specifically, coronary lesions caused by the pressure of the gas bubble resulted from the pressure difference in the blood vessels. In addition, the research team at TTU discovered that the rupture of gas bubbles in the coronary arteries is most likely the mechanism breaking the thin cap of plaque causing acute coronary syndrome. As an experienced expert in the field of cardiovascular interventions, Prof. Thach Nguyen has assisted his students in finding out techniques in acupuncture, ensuring better treatment results for patients with heart failure. Non-invasive left ventricular end diastolic pressure method has been also identified by the research team of TTU medical students, promising to be widely used as a substitute for old invasive methods.
The achievements mentioned above are also the result of collaborative research with doctors from many prestigious hospitals and universities around the world such as Rovigo General Hospital (Italy); Methodist Hospital (USA); Tulane University (New Orleans, USA); University of Chicago (USA), Indiana University (USA).
At present, the cardiac intervention method is already working, helping to address coronary artery obstruction and to treat myocardial infarction. This method is called stent placement. Although angioplasty for stent placement is highly successful (up to about 90 to 95% success rate), this is an invasive procedure that can cause bleeding and, at the same time, carries a greater risk of coronary artery stenosis or other risks such as bleeding, infections and drug allergies. The study at TTU has contributed to adjusting and improving stent placement procedure as well as limiting and detecting possible risks after the patient is discharged.
Hopefully, these achievements will be a source of motivation for students and faculties in the School of Medicine and for other research departments in TTU to keep up their good work in the path of successful learning and researching in the years ahead.
Thach N.Nguyen, Nhan Minh Tri Nguyen, Vien Thanh Truong, Viet Minh Vo, Gianluca Rigatelli Cavitation phenomenon creating bubbles and their explosion in the coronary arteries caused damage to the endothelium and start the atherosclerotic process J of the Am Coll of Cardiol Volume 71, Issue 11, Supplement, 10–12 March 2018, Page A269 https://doi.org/10.1016/S0735-1097(18)30810-6
Thach N. Nguyen, Tuan Si Nguyen, Gianluca Rigatelli, Vien Truong, Lanh V. Nguyen and Nhan Minh Tri Nguyen NEW TEST WHICH CAN PREDICT WHICH PATIENT WILL BE READMITTED AFTER HOSPITALIZATION FOR HEART FAILURE J of the Am Coll of Cardiol Volume 71, Issue 11 Supplement, March 2018 DOI: 10.1016/S0735-1097(18)31259-2
Marco Zuin, Thach Nguyen, Thao Dang, Ai Vu, Phuoc Luong, Tarneem Darwish, Tu Nguyen, Tuan Nguyen, QUoc Bui, Khoi Che, Thy Dang, Gianluca Rigatelli, Ernest Talarico Mechanism Triggering Acute Coronary Syndrome by Rupturing Plaque Based on the Cavitation Phenomenon (Bubble Formation and Explosion) at the Distal Left Main Bifurcation by Computational Fluid Dynamic Study Journal of the American College of Cardiology September 25, 2018, 72 (13 Supplement) B126-B127; DOI: 10.1016/j.jacc.2018.08.1447
Marco Zuin, Thach Nguyen, Hoa Bui, Thao Dang, Ai Vu, Tarneem Darwish, Thy Dang, Khoi Che, QUoc Bui, Ngoc Hoang, Tuan Nguyen, Gianluca Rigatelli, Ernest Talarico A 75% Stenosis Created Turbulent FLow, Ruptured Bubbles (Cavitation Phenomenon), Eroded the Vulnerable Cap and Triggered Acute Myocardial Infarction Journal of the American College of Cardiology September 25, 2018, 72 (13 Supplement) B341-B342; DOI: 10.1016/j.jacc.2018.08.2105
Gianluca Rigatelli, Marco Zuni, Vu Ha Thuy Vi, Duong Danh Nguyen Hien, Thao Dang and Thach Nguyen Left Main Bifurcation Stenting Assessed by Computational Fluid Dynamic: the Impact on Wall Shear Stress Forces Depends on Both Specific Techniques and Bifurcation Angles Volume 72, Issue 16 Supplement, October 2018 DOI: 10.1016/j.jacc.2018.08.596
Thach Nguyen, Thao Dang, Tu NT. Nguyen, Tran Huynh Thu Dung, Thai Ba Anh Minh, Nguyen Hua Hoang Quan, Tarneem Darwish, Gianluca Rigatelli Two-year Follow-up of a New Test which Correctly Predicted Which Patients with Borderline Hypotension Might Develop Hypotension within the Next 24 Hours Journal of the American College of Cardiology October 16, 2018, 72 (16 Supplement) C165; DOI: 10.1016/j.jacc.2018.08.744
Thach Nguyen, Thao Dang, Tu NT. Nguyen, Nguyen Phuoc Loc, Nguyen Bao Minh Nhu, Gianluca Rigatelli Best test to measure non-invasively the pulmonary artery wedge pressure and the left ventricular end diastolic pressure Journal of the American College of Cardiology October 16, 2018, 72 (16 Supplement) C192; DOI: 10.1016/j.jacc.2018.08.844
Thach Nguyen, Nguyen Bao Tran Chau, Luu Thi Phuong Thuy, Thao Dang, Tu NT. Nguyen, Tarneem Darwish, Gianluca Rigatelli, Ernest Talarico NEW DISCOVERY: New Technique of Visualization of Laminar, Turbulent Flow and Measurement of Velocity and dynamic coronary pressure Journal of the American College of Cardiology October 16, 2018, 72 (16 Supplement) C200; DOI: 10.1016/j.jacc.2018.08.872
Thach Nguyen, Tran Ngoc Minh Chau, Nguyen Tri Si, Thao Dang, Tu NT. Nguyen, Tarneem Darwish, Gianluca Rigatelli, Ernest Talarico Differences in Physical Examination of Patients with Symptomatic and Asymptomatic Fluid Overload and Low Ejection fraction Journal of the American College of Cardiology October 16, 2018, 72 (16 Supplement) C165; DOI: 10.1016/j.jacc.2018.08.743
Thach Nguyen, Thao Dang, Tu NT. Nguyen, Le Dieu Anh, Le Nhan Tam, Tarneem Darwish, Gianluca Rigatelli Assessment of the Blood Flow in the Subepicardial and Subendocardial Myocardium Before and After Percutaneous Coronary Interventions Journal of the American College of Cardiology October 16, 2018, 72 (16 Supplement) C125; DOI: 10.1016/j.jacc.2018.08.595
Thach Nguyen, Bi Duy Tan, Le Phu Kinh Quoc, Thao Dang, Tu NT. Nguyen, Tarneem Darwish, Gianluca Rigatelli, Ernest Talarico Differences in Myocardial Transit Time of Patients with Dilated Cardiomyopathy Journal of the American College of Cardiology October 16, 2018, 72 (16 Supplement) C164; DOI: 10.1016/j.jacc.2018.08.741
Thach Nguyen, Thao Dang, Tu NT. Nguyen, Cat Hoang Anh, Pham Le Huy Hoang, Tarneem Darwish, Gianluca Rigatelli, Ernest Talarico NEW DISCOVERY: Gas Bubbles Rupture in the Coronary Arteries is Most Likely the Mechanism Breaking the Thin Cap of Plaques Causing Acute Coronary Syndrome Journal of the American College of Cardiology October 16, 2018, 72 (16 Supplement) C105; DOI: 10.1016/j.jacc.2018.08.528
Thach Nguyen, Marco Zuni, Nguyen Thanh Luan, Nguyen Ngoc Huyen Vy, Kim Truong, Thao Dang, Tu NT. Nguyen, Tarneem Darwish, Gianluca Rigatelli, Ernest Talarico Demonstration of Cavitation in the Coronary Arteries by Computational Fluid Dynamic Journal of the American College of Cardiology October 16, 2018, 72 (16 Supplement) C72; DOI: 10.1016/j.jacc.2018.08.414
Thach Nguyen, Thao Dang, Phan Le Ngoc Ngan, Tu NT Nguyen, Dao Thanh Uyen Nhu, Nguyen Tran Kien An, Tarneem Darwish, Gianluca Rigatelli Optimal Status Markers for Heart Failure with Preserved Ejection Fraction Journal of the American College of Cardiology October 16, 2018, 72 (16 Supplement) C165-C166; DOI: 10.1016/j.jacc.2018.08.745
Gianluca Rigatelli, Marco Zuin, Thach Nguyen Left main bifurcation stenting assessed by computational fluid dynamic: The impact on wall shear stress forces depends on both specific techniques and bifurcation angles J Integr Cardiol, 2018 Volume 4(5): 1-7
Gianluca Rigatelli1, Marco Zuin, Fabio Dell’Avvocata1 Ramesh Daggubati, Aravinda Nanjundappa, Thach Nguyen Non-invasive evaluation of fluid dynamic of aortoiliac atherosclerotic disease: Impact of bifurcation angle and different stent configurations J of Translational Internal Medicine 6:3, July 2018
Thach Nguyen, Nguyen Van Lanh, Vo Minh Viet, Lam Hoang Phuc, Trung N. Pham, Khanh Duong, Luke Ashwin Lawrence, Vien T. Truong and Gianluca Rigatelli Advanced Strategies in the Diagnosis and Treatment of Patients with Coronary Artery Disease and Heart Failure: When Heart Failure Causes Ischemia and Angiotensin Converting Enzyme Inhibitor and Betablockers Helps in Diuresis Current Pharmaceutical Design, 2018, 24, 511-516